Surface Lin28A expression consistent with cellular stress parallels indicators of senescence.

Cellular phenotypic changes occurring in response to oxidative stress provides critical insights into biological processes of pathological injury and aging. Surface Lin28A is novel surface marker of oxidative stress conditions that cause DNA damage and cellular senescence. Accumulation of surface Lin28A was inhibited by antioxidant treatment with lowered indices of cellular stress and senescence, revealing the potential of surface Lin28A as a diagnostic stress marker. Furthermore, therapeutic strategies targeted toward surface Lin28 expression set the stage for next generation senolytics to remove stressed or senescent cells and promote recovery from tissue injury or aging.