Influenza A Virus Infection Induces Muscle Wasting via IL-6 Regulation of the E3 Ubiquitin Ligase Atrogin-1.
Kathryn A RadiganTrevor T NicholsonLynn C WelchMonica ChiLuciano AmarelleMartín AnguloMasahiko ShigemuraAtsuko ShigemuraConstance E RunyanLuisa Morales-NebredaHarris PerlmanErmelinda CecoEmilia LecuonaLaura A DadaAlexander V MisharinGokhan M MutluJacob I SznajderG R Scott BudingerPublished in: Journal of immunology (Baltimore, Md. : 1950) (2018)
Muscle dysfunction is common in patients with adult respiratory distress syndrome and is associated with morbidity that can persist for years after discharge. In a mouse model of severe influenza A pneumonia, we found the proinflammatory cytokine IL-6 was necessary for the development of muscle dysfunction. Treatment with a Food and Drug Administration-approved Ab antagonist to the IL-6R (tocilizumab) attenuated the severity of influenza A-induced muscle dysfunction. In cultured myotubes, IL-6 promoted muscle degradation via JAK/STAT, FOXO3a, and atrogin-1 upregulation. Consistent with these findings, atrogin-1+/- and atrogin-1-/- mice had attenuated muscle dysfunction following influenza infection. Our data suggest that inflammatory endocrine signals originating from the injured lung activate signaling pathways in the muscle that induce dysfunction. Inhibiting these pathways may limit morbidity in patients with influenza A pneumonia and adult respiratory distress syndrome.
Keyphrases
- skeletal muscle
- oxidative stress
- signaling pathway
- mouse model
- drug administration
- rheumatoid arthritis
- type diabetes
- diabetic rats
- endothelial cells
- electronic health record
- cell proliferation
- metabolic syndrome
- poor prognosis
- case report
- transcription factor
- risk assessment
- extracorporeal membrane oxygenation
- deep learning
- high glucose
- endoplasmic reticulum stress
- respiratory tract
- disease activity