Copper-Catalyzed Aminosulfonylation of O-Homoallyl Benzimidates with Sodium Sulfinates to Access Sulfonylated 1,3-Oxazines.

Wei DongZhuo-Yue FangTong-Yang CaoJie-Hui CaoZi-Qiang ZhaoLinlin ZhangWei LiLin QiLi-Jing Wang

Published in: Organic letters (2021)

A facile copper-catalyzed aminosulfonylation of O-homoallyl benzimidates with sodium sulfinates in the presence of tert-butyl peroxybenzoate (TBPB) and XPhos ligand has been developed. By using this protocol, a variety of potentially bioactive 1,3-oxazines were directly synthesized. This method has the merits of a cheap catalyst, easily available and stable sulfone reagents, and simple operation.

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