The novel pyridazine pyrazolecarboxamide insecticide dimpropyridaz inhibits chordotonal organ function upstream of TRPV channels.
Christian SpalthoffVincent L SalgadoNarayanan BaluMichael D DavidPhilip HehlertHuazhang HuangJohn E JonesRamani KandasamyGabriel A KnudsenKatherine R LelitoJames B MachamerNesterov AlexandreMichael TomalskiGregory D WahlBarbara J WedelMartin C GöpfertPublished in: Pest management science (2023)
PPCs are a new class of chordotonal organ modulator insecticide for control of piercing-sucking pests. Dimpropyridaz is a PPC proinsecticide that is activated in target insects to secondary amide forms that inhibit the firing of chordotonal organs. The inhibition occurs at a site upstream of TRPVs and is TRPV-independent, providing a novel mode of action for resistance management. © 2023 BASF Corporation. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.