Immunohistochemical expression of PAX8, PAX2, and cytokeratin in melanomas.
Jaclyn M PlotzkeRaymond ZhaoSteven M HrycajKelly L HarmsRohit MehraMay P ChanPublished in: Journal of cutaneous pathology (2021)
PAX8 is expressed in a subset of melanomas and may be strong/extensive. As PAX8 positivity does not exclude a diagnosis of melanoma, it should be used in conjunction with other immunohistochemical markers, such as cytokeratin and PAX2, when melanoma, MiTF-RCC, and other PAX8+ tumors are in the differential diagnosis.