N6-methyladenosine-modified circPLPP4 sustains cisplatin resistance in ovarian cancer cells via PIK3R1 upregulation.

Han LiRun LinYanna ZhangYanni ZhuShuting HuangJing LanNian LuChuanmiao XieShanyang HeWeijing Zhang

Published in: Molecular cancer (2024)

A -induced circPLPP4/ miR-136/ PIK3R1 axis mediated CDDP resistance in OC, suggesting that circPLPP4 may serve as a promising therapeutic target against CDDP resistant OC. A circPLPP4-targeted drug in combination with CDDP might represent a rational regimen in OC.

Keyphrases

cell proliferation
long non coding rna
drug induced
poor prognosis
high glucose
diabetic rats
long noncoding rna
signaling pathway
oxidative stress