In vitro cytotoxicity activity of novel Schiff base ligand-lanthanide complexes.
Kavitha AndiappanAnandhavelu SanmugamEaswaramoorthy DeivanayagamK KaruppasamyHyun-Seok KimDhanasekaran VikramanPublished in: Scientific reports (2018)
A Schiff base ligand (SBL), N2, N3-bis (anthracen-9-ylmethylene) pyridine-2, 3-diamine, was synthesized through the condensation of 2,6-diaminopyridine and anthracene-9-carbaldehyde using a 1:2 ratio. 1H NMR spectra confirmed the observation of non-involvement aromatic carboxylic proton in SBL. A novel series of lanthanide (i.e., praseodymium (Pr), erbium (Er), and ytterbium (Yb))-based SBL metal complexes was successfully synthesized, and their functional groups were elaborately demonstrated using UV-visible, Fourier transform infrared (FT-IR), and fluorescence spectroscopy analyses. FT-IR spectral studies revealed that SBL behaved as a bidentate ligand and it was structured with metal ions by the two azomethine nitrogens. The synthesized SBL-based metal complexes were elaborately performed for cytotoxicity activity versus Vero, human breast cancer (MCF7), and cervical (HeLa) anticancer cell lines.
Keyphrases
- single molecule
- energy transfer
- high resolution
- endothelial cells
- breast cancer cells
- magnetic resonance
- quantum dots
- solid state
- metal organic framework
- optical coherence tomography
- single cell
- oxide nanoparticles
- magnetic resonance imaging
- aqueous solution
- pluripotent stem cells
- cell death
- cell cycle arrest
- pi k akt