Functional Analysis of BRCA1 3'UTR Variants Predisposing to Breast Cancer.

Diana Carolina Sierra-DíazRodrigo CabreraLaura Alejandra Gonzalez-VasquezMariana Angulo-AguadoKevin Llinás-Caballero Dora Janeth Fonseca MendozaNora Constanza Contreras-BravoCarlos Martin RestrepoOscar Ortega-RecaldeAdrien Morel

Published in: The application of clinical genetics (2024)

The variant seems to protect against Triple Negative BC probably due to the expression level of miRNA in this particular cell line (MDA-MB-231). This is consistent with the clinical history of the patients who harbor BC Hormone Receptors positive (HR+).

Keyphrases

poor prognosis
copy number
breast cancer risk
breast cancer cells
gene expression
long non coding rna
cell proliferation
cell cycle arrest
genome wide