Prediction of the development of islet autoantibodies through integration of environmental, genetic, and metabolic markers.

Bobbie-Jo M Webb-Robertson Lisa M Bramer Bryan A StanfillSarah M ReehlErnesto S Nakayasu Thomas O Metz Brigitte I Frohnert Jill M Norris Randi K Johnson Stephen S Rich Marian J Rewers

Published in: Journal of diabetes (2020)

The majority (86%) of metabolites that predicted development of islet autoantibodies belonged to three pathways: lipid oxidation, phospholipase A2 signaling, and pentose phosphate, suggesting that these metabolic processes may play a role in triggering islet autoimmunity.

Keyphrases

systemic lupus erythematosus
ms ms
genome wide
hydrogen peroxide
dna methylation
gene expression
copy number
risk assessment