Thermal ablation compared to stereotactic body radiation therapy for hepatocellular carcinoma: A multicenter retrospective comparative study.
Andrew M MoonHannah P KimAmit G SingalDawn OwenMishal Mendiratta-LalaNeehar D ParikhSteven C RoseKatrina A McGintyChris B AgalaLauren M B BurkeAnjelica AbateErsan AltunChristian BeyerJohn DoMichael R FolkertChalon ForbesJona A Hattangadi-GluthPaul H HayashiKeri JonesGaurav KhatriYuko KonoTheodore S LawrenceChristopher MaurinoDavid M MauroCharles S MayoTaemee PakPreethi PatilEmily C SandersDaniel R SimpsonJoel E TepperDiwash ThapaTed K YanagiharaKyle WangDavid A GerberPublished in: Hepatology communications (2023)
In this multicenter study of patients with HCC, SBRT was associated with a lower risk of local progression compared to thermal ablation but higher all-cause mortality. Survival differences may be attributable to residual confounding, patient selection, or downstream treatments. These retrospective real-world data help guide treatment decisions while demonstrating the need for a prospective clinical trial.
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