Population pharmacokinetics of carboplatin, etoposide and melphalan in children: a re-evaluation of paediatric dosing formulas for carboplatin in patients with normal or mild impairment of renal function.

Janna K Duong Gareth J VealC E NathP J ShawJ ErringtonR LadensteinAlan V Boddy

Published in: British journal of clinical pharmacology (2018)

GFR did not appear to influence the pharmacokinetics of carboplatin after adjusting pharmacokinetic parameters for weight. This model-based approach validates the use of weight-based dosing as an appropriate alternative for carboplatin in children with either mild renal impairment or normal renal function.

Keyphrases

phase ii study
phase iii
young adults
body mass index
weight loss
physical activity
open label
intensive care unit
emergency department
weight gain
high dose
locally advanced
body weight
randomized controlled trial
clinical trial
squamous cell carcinoma
radiation therapy