A GITRL-mTORC1-GM-CSF Positive Loop Promotes Pathogenic Th17 Response in Primary Sjögren Syndrome.
Yuzhou GanHaotian ZhouYixue GuoBo HuangHongjiang LiuZiye WangZijun LiXiaozhen ZhaoHuaqun ZhuQimao HanHua YeJing HeQingwen WangZhanguo LiXiaolin SunPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2024)
Our results identified the pathogenic role of GITRL in exacerbating disease activity and promoting pathogenic Th17 response in pSS through a GITRL-mTORC1-GM-CSF loop. These findings suggest GITRL might be a promising therapeutic target in the treatment of pSS.