Comment on "ALK is a therapeutic target for lethal sepsis".
Rafael B BlascoEnrico PatruccoInes MotaWei-Tien TaiRoberto ChiarlePublished in: Science translational medicine (2019)
Physiologically relevant ALK (anaplastic lymphoma kinase) expression was not detected in human and mouse monocytes and macrophages, suggesting that the effects of bioactive compounds on stimulator of interferon genes (STING) activation may not depend on ALK.
Keyphrases
- advanced non small cell lung cancer
- endothelial cells
- dendritic cells
- poor prognosis
- intensive care unit
- acute kidney injury
- diffuse large b cell lymphoma
- epidermal growth factor receptor
- induced pluripotent stem cells
- binding protein
- septic shock
- immune response
- gene expression
- long non coding rna
- genome wide identification