Melatonin In Acute Mania Investigation (MIAMI-UK). A randomized controlled trial of add-on melatonin in bipolar disorder.

Digby J QuestedJessica C GibsonAnn L SharpleyJulia H CordeyAlexis EconomouFranco De CrescenzoMerryn VoyseyJennifer LawsonJennifer M RendellHasanen Al-TaiarAlison LennoxFarooq AhmadJohn R Geddes

Published in: Bipolar disorders (2020)

In this small trial, melatonin did not effectively treat emerging hypomania or mania as there was no significant difference on the primary outcome. The sample size limitation and secondary outcomes suggest further investigation of melatonin treatment in mood episodes is indicated.

Keyphrases

bipolar disorder
major depressive disorder
liver failure
study protocol
intensive care unit
respiratory failure
randomized controlled trial
depressive symptoms
physical activity
metabolic syndrome
combination therapy
phase ii
skeletal muscle
acute respiratory distress syndrome
replacement therapy
glycemic control