Psychophysical pain encoding in the cingulate cortex predicts responsiveness of electrical stimulation.

Rose M CastonElliot H SmithTyler S DavisHargunbir Singh Shervin Rahimpour John D Rolston

Published in: medRxiv : the preprint server for health sciences (2023)

Stimulation of cingulate regions with increased pain-related neural activity was more effective at modulating pain perception than stimulating non-responsive areas. Personalized evaluation of neural activity biomarkers could help identify the best target for stimulation and predict its effectiveness in future studies evaluating DBS.

Keyphrases

chronic pain
pain management
neuropathic pain
functional connectivity
spinal cord injury
systematic review
randomized controlled trial
cancer therapy
drug delivery