Inferring the role of the microbiome on survival in patients treated with immune checkpoint inhibitors: causal modeling, timing, and classes of concomitant medications.
Daniel J SpakowiczRebecca HoydMitchell MuniakMarium HusainJames S BassettLei WangGabriel TinocoSandip H PatelJarred BurkartAbdul MiahMingjia LiAndrew JohnsMadison GroganDavid P CarboneClaire F VerschraegenKari L KendraGregory A OttersonLang LiCarolyn J PresleyDwight H OwenPublished in: BMC cancer (2020)
The timing and strength of the correlations with antibiotics and corticosteroids after controlling for confounding factors are consistent with the microbiome involvement with the response to ICIs across several cancers.
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