Efficacy of perineural hypertonic saline injection versus acupoints of foot in the management of diabetic neuropathy: a multicenter, double-blinded randomized controlled trial.
Nina HeidariAlireza AshrafLeila Sadat Mohamadi JahromiReyhaneh ParvinPublished in: Pain management (2022)
Aim: Painful diabetic polyneuropathy is one of the most common disabling problems worldwide. We aimed to determine if a perineural injection of hypertonic saline compared with foot acupoints decreased the neuropathic pain score in patients with diabetes. Patients & methods/materials: Patients were assigned to receive either perineural or acupoints injection of hypertonic saline 5% in their feet for three weekly sessions. Douleur Neuropathique 4 (DN4) questionnaire for neuropathic pain was assessed. Results: Both groups observed a significant reduction of the DN4 score throughout 8 weeks of follow-up. Conclusion: Both perineural and acupoints hypertonic saline injections of the foot could improve neuropathic pain in patients with diabetes.
Keyphrases
- neuropathic pain
- spinal cord
- spinal cord injury
- end stage renal disease
- randomized controlled trial
- ejection fraction
- newly diagnosed
- chronic kidney disease
- type diabetes
- ultrasound guided
- peritoneal dialysis
- mental health
- prognostic factors
- systematic review
- clinical trial
- study protocol
- patient reported outcomes
- preterm birth
- platelet rich plasma