Low-dose ionizing γ-radiation elicits the extrusion of neutrophil extracellular traps.

Alvaro Teijeira Saray Garasa María Carmen Ochoa Sandra Sanchez-Gregorio Gabriel Gomis Carlos Luri-Rey Rafael Martinez-Monge Beatrice Pinci Karmele Valencia Belen Palencia Benigno Barbes Elixabet Bolaños Arantza Azpilikueta Marina Garcia-Cardosa Javier Burguete Iñaki Eguren Eneko Garate-Soraluze Pedro Berraondo Jose-Luis Perez-Gracia Carlos E De Andrea Maria E Rodríguez-Ruiz Ignacio Melero Bermejo

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

NETosis is induced by low-dose ionizing irradiation in a neutrophil-intrinsic fashion and radiation-induced NETs are able to interfere with immune-mediated cytotoxicity. Radiation-induced NETs foster metastasis in mouse models and can be detected in the circulation of patients undergoing conventional radiotherapy treatments.

Keyphrases

radiation induced
low dose
patients undergoing
radiation therapy
high dose
mouse model
squamous cell carcinoma
locally advanced