Increased ferroptosis in leukocytes from preeclamptic women involving the long non-coding taurine upregulated gene 1 (TUG1).

Tove LekvaAnnika Elisabet MichelsenMarie Cecilie Paasche RolandErrol R NorwitzMette-Elise EstensenOle Kristoffer OlstadIbrahim A AkkouhTore HenriksenJens BollerslevPål AukrustThor Ueland

Published in: Journal of internal medicine (2023)

Our findings suggest that maternal leukocytes in PE show decreased anti-ferroptotic activity that correlates with anti-inflammatory expression. Moreover, some of these changes in ferroptotic activity appear to precede the development of PE.

Keyphrases

anti inflammatory
peripheral blood
pregnancy outcomes
poor prognosis
cell death
polycystic ovary syndrome
copy number
pregnant women
metabolic syndrome
gene expression
dna methylation
binding protein
weight loss
weight gain