Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice.

Takashi MatsuzakaMotoko KubaSaori KoyasuYuta YamamotoKaori MotomuraSundaram ArulmozhirajaHiroshi OhnoRahul SharmaTakuya ShimuraYuka OkajimaSong-Iee HanYuichi AitaYuhei MizunoeYoshinori OsakiHitoshi IwasakiShigeru YatohHiroaki SuzukiYasuhiro MatsubayashiYoshinori TakeuchiNaoya YahagiTakafumi MiyamotoMotohiro SekiyaYoshimi NakagawaMasatsugu EmaSatoru TakahashiHiroaki TokiwaHitoshi Shimano

Published in: Hepatology (Baltimore, Md.) (2020)

Our study demonstrates the key role of hepatic Elovl6 in the regulation of the acyl-chain composition of ceramide and that C18:0-ceramide is a potent regulator of hepatic insulin signaling linked to Pnpla3-mediated NAFLD.

Keyphrases

fatty acid
type diabetes
transcription factor
high fat diet induced
metabolic syndrome
insulin resistance
liver injury