A CRISPR activation screen identifies MUC-21 as critical for resistance to NK and T cell-mediated cytotoxicity.

Dong-Hee LeeHyejin AhnHye-In SimEunji ChoiSeunghyun ChoiYunju JoBohwan YunHyun Kyu SongSoo Jin OhKaori Denda-NagaiChan-Sik ParkTatsuro IrimuraYoon Park Hyung-Seung Jin

Published in: Journal of experimental & clinical cancer research : CR (2023)

T cell attacks. This suggests that inhibiting MUC21 could be a promising strategy to improve cancer immunotherapy.

Keyphrases

genome wide
crispr cas
genome editing
signaling pathway
high throughput
dna methylation
nk cells