Sciatic nerve stimulation alleviates neuropathic pain and associated neuroinflammation in the dorsal root ganglia in a rodent model.
Chia-En WongWentai LiuChi-Chen HuangPo-Hsuan LeeHan-Wei HuangYu ChangHsin-Tien LoHui-Fang ChenLi-Chieh KuoJung-Shun LeePublished in: Journal of translational medicine (2024)
NRL induced hyperactivation of SGCs, which had increased expression of NP-related ion channels. Reciprocal activation of SGCs and M1 macrophages surrounding the primary sensory neurons was mediated by the HIF-1α and NF-κB pathways. SNS suppressed SGC hyperactivation and skewed M1 macrophage towards M2. Our findings establish SGC activation as a crucial pathomechanism in the gliopathic alterations in NP, which can be modulated by SNS neuromodulation.
Keyphrases
- neuropathic pain
- spinal cord
- spinal cord injury
- lps induced
- poor prognosis
- signaling pathway
- traumatic brain injury
- high glucose
- diabetic rats
- adipose tissue
- oxidative stress
- lipopolysaccharide induced
- drug induced
- endothelial cells
- inflammatory response
- binding protein
- cell proliferation
- toll like receptor
- blood brain barrier