NfL reliability across laboratories, stage-dependent diagnostic performance and matrix comparability in genetic FTD: a large GENFI study.
Christoph LinnemannCarlo WilkeDavid MengelHenrik ZetterbergCarolin HellerJens KuhleArabella BouziguesLucy L RussellPhoebe H FosterEve Ferry-BolderJohn Cornelis van SwietenLize C JiskootHarro SeelaarFermin MorenoBarbara BorroniRaquel Sánchez-ValleDaniela GalimbertiRobert LaforceCaroline GraffMario MasellisMaria Carmela TartagliaJames Benedict RoweElizabeth C FingerRik VandenbergheAlexandre de MendoncaChris R ButlerAlexander GerhardSimon DucharmeIsabelle L E BerPietro TiraboschiIsabel SantanaFlorence PasquierJohannes LevinMarkus OttoSandro SorbiJonathan Daniel RohrerMatthis Synofziknull nullPublished in: Journal of neurology, neurosurgery, and psychiatry (2024)
Our results underline the suitability of blood NfL in gFTD multicentre trials, including cross-lab reliable stratification of the highly trial-relevant conversion stage, matrix comparability and cross-site robustness.