Clinical characteristics of HFrEF patients with rare pathogenic variants in DCM-associated genes: a subgroup analysis of the PARADIGM-HF trial.
Ana BaratChien-Wei ChenNatasha Patel-MurrayJohn J V McMurrayMilton PackerScott D SolomonAkshay S DesaiJean L RouleauMichael R ZileZenab AttariCong ZhangHuilei XuNicole HartmanClaudia HonMargaret HealeyWilliam ChutkowChristopher J O'DonnellJaison JacobMarty LefkowitzMichael M MendelsonSimon WandelDenise YatesClaudio R GimpelewiczPublished in: European journal of heart failure (2023)
Deleterious pLoF variants in genes with definitive/strong association to DCM were identified in ~5% of HFrEF patients from a PARADIGM-HF trial subset, who were younger, had lower EF and were less likely to have had an ischaemic aetiology. This article is protected by copyright. All rights reserved.