The Preventive Effect of Low-Molecular Weight Oyster Peptides on Lipopolysaccharide-Induced Acute Colitis in Mice by Modulating Intestinal Microbiota Communities.
Qihang WuHaisheng LinWeiqiang ShenWenhong CaoXiaoming QinJialong GaoZhongqin ChenHuina ZhengSaiyi ZhongHaoyang HuangPublished in: Foods (Basel, Switzerland) (2024)
Colitis causes inflammation, diarrhoea, fever, and other serious illnesses, posing a serious threat to human health and safety. Current medications for the treatment of colitis have serious side effects. Therefore, the new strategy of creating a defence barrier for immune function by adding anti-inflammatory foods to the daily diet is worth advocating for. Low-molecular weight oyster peptides (LOPs) are a natural food with anti-inflammatory activity extracted from oysters, so intervention with LOPs is likely to be an effective preventive solution. The aim of this study was to investigate the preventive effect of LOPs on lipopolysaccharide (LPS)-induced acute colitis inflammation in mice and its underlying mechanism. The results showed that LOPs not only inhibited the colonic histopathy in mice induced by LPS-induced inflammation but also reduced the inflammatory response in the blood. In addition, LOPs significantly increased the number of beneficial bacteria ( Alistipes , Mucispirillum , and Oscillospira ), decreased the number of harmful bacteria ( Coprobacillus , Acinetobater ) in the intestinal microbiota, and further affected the absorption and utilisation of short-chain fatty acids (SCFAs) in the intestinal tract. In conclusion, dietary supplementation with LOPs is a promising health-promoting dietary supplement and nutraceutical for the prevention of acute colitis by reducing the inflammatory response and modulating the intestinal microbial communities.
Keyphrases
- inflammatory response
- lipopolysaccharide induced
- lps induced
- human health
- ulcerative colitis
- toll like receptor
- oxidative stress
- high fat diet induced
- risk assessment
- liver failure
- anti inflammatory
- fatty acid
- respiratory failure
- physical activity
- healthcare
- public health
- signaling pathway
- climate change
- mental health
- type diabetes
- drug induced
- wild type
- extracorporeal membrane oxygenation
- hepatitis b virus
- aortic dissection
- acute respiratory distress syndrome
- skeletal muscle
- metabolic syndrome
- combination therapy