How do they add up? The interaction between the placebo and treatment effect: A systematic review.

Rémy BoussageonJeremy HowickRaphael BaronFlorian Naudet Bruno FalissardGhina Harika-GermaneauIssa WassoufFrançois Gueyffier Nemat Jaafari Blanchard Clara

Published in: British journal of clinical pharmacology (2022)

Evidence of additivity between placebo and specific features of treatments was rare in included studies. We suggest interventions for placebo-sensitive ailments should be tested in trials designed to take interactions seriously once an exploratory RCTs has proven their efficacy with sufficient internal validity.

Keyphrases

double blind
phase iii
placebo controlled
physical activity
clinical trial
randomized controlled trial
case control