A phase III randomized controlled trial of radiation dose optimization in non-Hodgkin lymphoma-diffuse large B-cell lymphoma (DOBL study): Study protocol and design.
Jayant Sastri GodaShirly C LewisSiddartha LaskarSadhna KannanNehal KhannaHasmukh JainBhausaheb BagalSridhar EpariPublished in: Cancer reports (Hoboken, N.J.) (2019)
The study is designed to test the noninferiority of radiation dose de-escalation in a uniform cohort of patients diagnosed with DLBCL and treated with R-CHOP regimen in the post-positron emission tomography (PET) era. The trial is rigorously designed and is straightforward to implement. It is statistically powered to answer if reducing the radiation doses does not compromise the clinical outcome in the given patient cohort. This trial will effectively set the standards in radiotherapy doses for DLBCL in the contemporary era.
Keyphrases
- diffuse large b cell lymphoma
- phase iii
- study protocol
- positron emission tomography
- randomized controlled trial
- open label
- clinical trial
- computed tomography
- epstein barr virus
- phase ii
- newly diagnosed
- ejection fraction
- pet ct
- end stage renal disease
- pet imaging
- placebo controlled
- systematic review
- radiation induced
- patient reported outcomes
- rectal cancer
- patient reported