Choice of Glucose-Lowering Drugs as Initial Monotherapy for Type 2 Diabetes Patients with Contraindications or Intolerance to Metformin: A Systematic Review and Meta-Analysis.

Shuyan GuXiaoqian HuLizheng Shi Xuemei ZhenXueshan SunMinzhuo HuangYuxuan GuHengjin Dong

Published in: Journal of clinical medicine (2022)

Our results suggest a potential treatment hierarchy for decision-makers, with GLP-1RAs being the preferred alternative therapy to metformin regarding their favorable efficacy and safety profiles.

Keyphrases

type diabetes
combination therapy
decision making
cardiovascular disease
blood glucose
glycemic control
randomized controlled trial
clinical trial
stem cells
adipose tissue
blood pressure
risk assessment
replacement therapy
bone marrow
weight loss
drug induced