Nkx-2.5 Regulates MDR1 Expression via Its Upstream Promoter in Breast Cancer Cells.

Jung-Suk Lim Gyu Yeon Jung Seung-Yoon Park

Published in: Journal of Korean medical science (2019)

The results in the present study show Nkx-2.5 is a positive regulator for the transactivation of MDR1 USP in MCF7 breast cancer cells. Our findings will help elucidate the regulatory mechanism responsible for the multidrug resistant cancer phenotype.

Keyphrases

breast cancer cells
multidrug resistant
transcription factor
drug resistant
gram negative
acinetobacter baumannii
klebsiella pneumoniae
poor prognosis
papillary thyroid
dna methylation
gene expression
squamous cell
pseudomonas aeruginosa
long non coding rna
cystic fibrosis
lymph node metastasis