Assessing Therapeutic Efficacy in Real-time by Hyperpolarized Magnetic Resonance Metabolic Imaging.
Prasanta DuttaTravis C SalzilloShivanand PudakalakattiSeth T GammonBenny A KaipparettuFlorencia McAllisterShawn WagnerDaniel E FrigoChristopher J LogothetisNiki M ZachariasPratip K BhattacharyaPublished in: Cells (2019)
Precisely measuring tumor-associated alterations in metabolism clinically will enable the efficient assessment of therapeutic responses. Advances in imaging technologies can exploit the differences in cancer-associated cell metabolism as compared to normal tissue metabolism, linking changes in target metabolism to therapeutic efficacy. Metabolic imaging by Positron Emission Tomography (PET) employing 2-fluoro-deoxy-glucose ([18F]FDG) has been used as a routine diagnostic tool in the clinic. Recently developed hyperpolarized Magnetic Resonance (HP-MR), which radically increases the sensitivity of conventional MRI, has created a renewed interest in functional and metabolic imaging. The successful translation of this technique to the clinic was achieved recently with measurements of 13C-pyruvate metabolism. Here, we review the potential clinical roles for metabolic imaging with hyperpolarized MRI as applied in assessing therapeutic intervention in different cancer systems.
Keyphrases
- positron emission tomography
- magnetic resonance
- high resolution
- computed tomography
- contrast enhanced
- pet ct
- magnetic resonance imaging
- primary care
- randomized controlled trial
- stem cells
- type diabetes
- mass spectrometry
- adipose tissue
- risk assessment
- blood pressure
- insulin resistance
- bone marrow
- diffusion weighted imaging
- human health