Biologic TNF-α inhibitors reduce microgliosis, neuronal loss, and tau phosphorylation in a transgenic mouse model of tauopathy.

Weijun OuJoshua YangJuste SimanauskaiteMatthew ChoiDemi M CastellanosRudy ChangJiahong SunNataraj JagadeesanKaren D ParfittDavid H CribbsRachita K Sumbria

Published in: Journal of neuroinflammation (2021)

Both TfRMAb-TNFR (BBB-penetrating) and non-BBB-penetrating (etanercept) biologic TNFIs showed therapeutic effects in the PS19 mouse model of tauopathy.

Keyphrases

rheumatoid arthritis
mouse model
blood brain barrier
disease activity
ankylosing spondylitis
cerebral ischemia
rheumatoid arthritis patients
protein kinase
brain injury
subarachnoid hemorrhage