Transcriptomic analysis of monocytes from HIV-positive men on antiretroviral therapy reveals effects of tobacco smoking on interferon and stress response systems associated with depressive symptoms.
David R LorenzVikas MisraDana GabuzdaPublished in: Human genomics (2019)
This study characterizes immune, interferon, stress response, and mitochondrial-associated gene expression changes in monocytes from HIV+ tobacco smokers, and identifies augmented interferon and stress responses associated with depressive symptoms. These findings help to explain complex interrelationships between pro-inflammatory effects of HIV and smoking, and their combined impact on comorbidities prevalent in HIV+ individuals.
Keyphrases
- hiv positive
- antiretroviral therapy
- hiv infected
- depressive symptoms
- human immunodeficiency virus
- men who have sex with men
- dendritic cells
- hiv infected patients
- hiv aids
- gene expression
- south africa
- smoking cessation
- hiv testing
- social support
- dna methylation
- oxidative stress
- hepatitis c virus
- peripheral blood
- middle aged