Influenza virus infection increases ACE2 expression and shedding in human small airway epithelial cells.
Kelly S SchweitzerTaylor CrueJordan M NallDaniel FosterSatria P SajuthiKelly A CorrellMari NakamuraJamie L EvermanGregory P DowneyMax A SeiboldJames P BridgesKarina A SerbanHong Wei ChuIrina PetrachePublished in: The European respiratory journal (2021)
These results indicate that IAV amplifies the expression of molecules necessary for SARS-CoV-2 infection of the distal lung. Furthermore, post-translational changes in ACE2 by IAV may increase vulnerability to lung injury such as acute respiratory distress syndrome during viral co-infections. These findings support efforts in the prevention and treatment of influenza infections during the COVID-19 pandemic.
Keyphrases
- acute respiratory distress syndrome
- poor prognosis
- extracorporeal membrane oxygenation
- mechanical ventilation
- endothelial cells
- angiotensin ii
- angiotensin converting enzyme
- sars cov
- climate change
- binding protein
- minimally invasive
- intensive care unit
- respiratory syndrome coronavirus
- coronavirus disease
- combination therapy