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Adaptation and validation of simple tools to screen and monitor for oral PrEP adherence.

Seth ZissetteElizabeth Ellen TolleyAndres MartinezHomaira HanifKatherine GillNelly MugoLaura MyersEdnar CasmirMenna DuyverKenneth NgureGustavo F Doncel
Published in: PloS one (2021)
Accurate measurement of HIV-prevention product adherence is of critical importance to the assessment of product efficacy and safety in clinical trials, and the support of safe and effective product use in non-trial settings. In this study, we provide further validation for these measures, demonstrating the screening tool's utility in additional populations and adapting the monitoring tool's utility for different HIV-prevention products.
Keyphrases
  • clinical trial
  • phase ii
  • phase iii
  • study protocol
  • men who have sex with men
  • high throughput
  • high resolution
  • open label
  • randomized controlled trial
  • type diabetes
  • adipose tissue
  • mass spectrometry
  • placebo controlled