Care Patterns and Overall Survival in Patients With Early-Onset Metastatic Colorectal Cancer.
Katie N KanterMadeleine G FishGianluca MauriNora K HorickJill N AllenLawrence S BlaszkowskyJeffrey W ClarkDavid P RyanRyan David NippBruce J GiantonioLipika GoyalJon DuboisJanet E MurphyJoseph W FransesSamuel J KlempnerEric J RoelandColin D WeekesJennifer Y WoTheodore S HongEmily E van SeventerRyan B CorcoranAparna Raj ParikhPublished in: JCO oncology practice (2021)
Despite patients with EO-CRC receiving more intensive treatments, survival was similar to the older counterpart. However, EO-CRC had clinical and molecular features associated with worse prognoses. Improved biologic understanding is needed to optimize clinical management of EO-CRC. The cost-benefit ratio of exposing patients with EO-CRC to more intensive treatments has to be carefully evaluated.