Standardized measurement of coronary inflammation using cardiovascular computed tomography: integration in clinical care as a prognostic medical device.
Evangelos K OikonomouAlexios S AntonopoulosDavid SchottlanderMohammad MarwanChris MathersPete TomlinsMuhammad SiddiqueLaura V KlünerCheerag ShirodariaMichail C MavrogiannisSheena ThomasAgostina FavaJohn DeanfieldKeith M ChannonStefan NeubauerMilind Y DesaiStephan AchenbachCharalambos AntoniadesPublished in: Cardiovascular research (2022)
Mapping of perivascular FAI on CCTA enables the non-invasive detection of coronary artery inflammation by quantifying spatial changes in perivascular fat composition. We now report the performance of a new medical device, CaRi-Heart®, which allows standardized measurement of coronary inflammation by calculating the FAI-Score of each coronary artery. The CaRi-Heart® device provides a reliable prediction of the patient's absolute risk for a fatal cardiac event by incorporating traditional cardiovascular risk factors along with comprehensive CCTA coronary plaque and perivascular adipose tissue phenotyping. This integration advances the prognostic utility of CCTA for individual patients and paves the way for its use as a dual diagnostic and prognostic tool among patients referred for CCTA.
Keyphrases
- coronary artery
- cardiovascular risk factors
- pulmonary artery
- adipose tissue
- oxidative stress
- healthcare
- coronary artery disease
- computed tomography
- end stage renal disease
- heart failure
- ejection fraction
- chronic kidney disease
- newly diagnosed
- high resolution
- atrial fibrillation
- metabolic syndrome
- prognostic factors
- insulin resistance
- magnetic resonance imaging
- peritoneal dialysis
- high throughput
- cardiovascular disease
- case report
- high fat diet
- quality improvement
- fatty acid
- pulmonary hypertension
- mass spectrometry
- pain management
- sensitive detection
- contrast enhanced
- aortic valve