Hydroxyacid Oxidase 2 (HAO2) Inhibits the Tumorigenicity of Hepatocellular Carcinoma and Is Negatively Regulated by miR-615-5p.
Yuxuan LiMingchao ZhangXiu-Ling LiYanyan WangYu WangYuan LiHuihui ZhuHui DingXiaofang LiSuofeng SunPublished in: Journal of immunology research (2022)
HAO2 was found to be underexpressed in HCC tissues and cells, and HAO2 overexpression inhibited HCC cell motility, which was negatively regulated by miR-615-5p. Exogenous expression of HAO2 reduced the tumorigenicity of HCC cells in vivo in nude mice.
Keyphrases
- induced apoptosis
- cell cycle arrest
- poor prognosis
- endoplasmic reticulum stress
- gene expression
- cell death
- single cell
- stem cells
- signaling pathway
- transcription factor
- cell therapy
- adipose tissue
- escherichia coli
- staphylococcus aureus
- long non coding rna
- biofilm formation
- pseudomonas aeruginosa
- cystic fibrosis
- high fat diet induced
- insulin resistance