Time dependent response of daunorubicin on cytotoxicity, cell cycle and DNA repair in acute lymphoblastic leukaemia.

Hussain Mubarak Al-AamriHeng KuHelen R IrvingJoseph TucciTerri Meehan-AndrewsChristopher Bradley

Published in: BMC cancer (2019)

The delay in DSB repair and lower sensitivity to daunorubicin seen in the B lymphocyte derived SUP-B15 cells could be due to loss of function of p53 that may be correlated to increased expression of SOD2 and lower ROS production.

Keyphrases

cell cycle
dna repair
dna damage
cell proliferation
poor prognosis
liver failure
dna damage response
respiratory failure
cell death
drug induced
amyotrophic lateral sclerosis
oxidative stress
intensive care unit
mechanical ventilation