Comparative efficacy and safety of caffeine citrate and aminophylline in treating apnea of prematurity: A systematic review and meta-analysis.

Yiqun MiaoYun ZhouShuliang ZhaoWenwen LiuAihua WangYuanyuan ZhangYanan LiHuimin Jiang

Published in: PloS one (2022)

This meta-analysis reveals that caffeine citrate and aminophylline have similar therapeutic effectiveness on respiratory function, but caffeine has fewer side effects and should be considered first for treatment.

Keyphrases

randomized controlled trial
obstructive sleep apnea
systematic review
preterm infants
combination therapy
positive airway pressure