Assessment of AXL and mTOR genes expression in medullary thyroid carcinoma (MTC) cell line in relation with over expression of miR-144 and miR-34a.

Shaghayegh PishkariRazie Hadavi Ameneh Koochaki Javad Razaviyan Mahdi Paryan Mehrdad Hashemi Samira Mohammadi-Yeganeh

Published in: Hormone molecular biology and clinical investigation (2021)

Based on the results of the present study and since AXL and mTOR genes play a critical role in variety of human cancers, suppression of these genes by their targeting miRNAs, especially miR-34a and miR-144, can be propose as a new strategy for MTC management. However, more studies are needed to approve the hypothesis.

Keyphrases

cell proliferation
long non coding rna
poor prognosis
long noncoding rna
genome wide
tyrosine kinase
endothelial cells
bioinformatics analysis
genome wide identification
gene expression
cancer therapy
young adults
transcription factor