Changes in systemic and subcutaneous adipose tissue inflammation and oxidative stress in response to exercise training in obese black African women.
Pamela Arielle Nono NankamAmy E MendhamMelony F De SmidtDheshnie KeswellTommy OlssonMatthias BlüherJulia H GoedeckePublished in: The Journal of physiology (2020)
Inflammation and oxidative stress are interrelated during obesity and contribute to the development of insulin resistance. Exercise training represents a key component in the management of obesity. We evaluated the effects of 12 weeks' combined resistance and aerobic exercise training on systemic and abdominal vs. gluteal subcutaneous adipose tissue (SAT) inflammatory and oxidative status in obese black South African women. Before and after the intervention, body composition (dual energy X-ray absorptiometry), cardio-respiratory fitness ( VO 2 peak ), serum and SAT inflammatory and oxidative stress markers were measured from 15 (control group) and 20 (exercise group) women and insulin sensitivity (SI ; frequently sampled intravenous glucose tolerance test) was estimated. Following the intervention, VO 2 peak (9.8%), body fat composition (1-3%) and SI (9%) improved, serum thiobarbituric acid reactive substances (TBARS) decreased (6.5%), and catalase activity increased (23%) in the exercise compared to the control group (P < 0.05), without changes in circulating inflammatory markers. The mRNA content of interleukin-10, tumour necrosis factor α, nuclear factor κB and macrophage migration inhibitory factor increased in the gluteal SAT exercise compared to the control group P < 0.05), with no changes in abdominal SAT. These changes of inflammatory profile in gluteal SAT, in addition to the reduction of circulating TBARS, correlated with the reduction of gynoid fat, but not with the improvement of SI . The changes in systemic oxidative stress markers and gluteal SAT inflammatory genes correlated with the reduction in gynoid fat but were not directly associated with the exercise-induced improvements in SI .
Keyphrases
- oxidative stress
- adipose tissue
- insulin resistance
- polycystic ovary syndrome
- body composition
- dual energy
- resistance training
- high fat diet
- high intensity
- skeletal muscle
- high fat diet induced
- nuclear factor
- diabetic rats
- dna damage
- metabolic syndrome
- ischemia reperfusion injury
- computed tomography
- bone mineral density
- physical activity
- randomized controlled trial
- induced apoptosis
- room temperature
- toll like receptor
- type diabetes
- weight loss
- high resolution
- pregnancy outcomes
- drinking water
- genome wide
- dna methylation
- pregnant women
- glycemic control
- gestational age
- low dose
- weight gain
- cervical cancer screening
- high dose
- inflammatory response
- transcription factor
- magnetic resonance imaging
- gene expression
- signaling pathway