Clinicopathological characteristics and outcomes of gastrointestinal stromal tumors with high progranulin expression.

In-Gu DoKyung Uk JungDong-Hoe KooYun-Gyoo LeeSukjoong OhKyungeun KimDong-Hoon KimJin Hee SohnByung Ho SonSung Ryol LeeJun Ho ShinHyung Ook KimHungdai KimHo-Kyung ChunGinette SerreroChang Hak Yoo

Published in: PloS one (2021)

High PGRN-expressing GISTs showed more epithelioid/mixed histology and KIT exon 11 mutations. PGRN overexpression was significantly associated with poor RFS in patients with GISTs who underwent curative resection.

Keyphrases

poor prognosis
cell proliferation
transcription factor
rectal cancer
binding protein
prognostic factors
adipose tissue
skeletal muscle