Divergent patterns of healthy aging across human brain regions at single-cell resolution reveal links to neurodegenerative disease.

Megan F Duffy Jinhui Ding Rebekah G LangstonSyed I ShahMike A NallsSonja W Scholz D Thad WhitakerPavan K AuluckStefano MarencoRaphael J Gibbs Mark R Cookson

Published in: bioRxiv : the preprint server for biology (2023)

Establishment of a single nuclei atlas of human aging in four brain regionsEach region and cell type exhibits a unique aging-associated transcriptome signatureGene expression changes occur in absence of overt cell loss and are categorically unique across cell typesNeurological disease-associated genes have age-associated expression patterns in specific cell types in the context of healthy aging.

Keyphrases

single cell
rna seq
high throughput
cell therapy
endothelial cells
gene expression
stem cells
binding protein
multiple sclerosis
transcription factor
mesenchymal stem cells
brain injury
long non coding rna
cerebral ischemia