Mark R Cookson

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 40

Top Topics

Gene Expression

Top Venues

bioRxiv : the preprint server for biology

Science translational medicine

Scientific reports

Journal of neurochemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Mallory Ryan, Justin A McDonough, Michael Emmerson Ward, Mark R Cookson, William C Skarnes, Florian T Merkle
Large structural variants in KOLF2.1J are unlikely to compromise neurological disease modelling. bioRxiv : the preprint server for biology (2024)
Mallory Ryan, Justin A McDonough, Michael Emmerson Ward, Mark R Cookson, William C Skarnes, Florian T Merkle
Large structural variants in KOLF2.1J are unlikely to compromise neurological disease modelling. bioRxiv : the preprint server for biology (2024)
Luis Bonet-Ponce, Tsion Tegicho, Alexandra Beilina, Jillian H Kluss, Yan Li, Mark R Cookson
Opposing actions of JIP4 and RILPL1 provide antagonistic motor force to dynamically regulate membrane reformation during lysosomal tubulation/sorting driven by LRRK2. bioRxiv : the preprint server for biology (2024)
Mallory Ryan, Justin A McDonough, Michael Emmerson Ward, Mark R Cookson, William C Skarnes, Florian T Merkle
Large structural variants in KOLF2.1J are unlikely to compromise neurological disease modelling. bioRxiv : the preprint server for biology (2024)
Luis Bonet-Ponce, Jillian H Kluss, Mark R Cookson
Mechanisms of lysosomal tubulation and sorting driven by LRRK2. Biochemical Society transactions (2024)
Mallory Ryan, Justin A McDonough, Michael Emmerson Ward, Mark R Cookson, William C Skarnes, Florian T Merkle
Large structural variants in KOLF2.1J are unlikely to compromise neurological disease modelling. bioRxiv : the preprint server for biology (2024)
Luis Bonet-Ponce, Jillian H Kluss, Mark R Cookson
Mechanisms of lysosomal tubulation and sorting driven by LRRK2. Biochemical Society transactions 52 (4) (2024)
Luis Bonet-Ponce, Tsion Tegicho, Alexandra Beilina, Jillian H Kluss, Yan Li, Mark R Cookson
Opposing actions of JIP4 and RILPL1 provide antagonistic motor force to dynamically regulate membrane reformation during lysosomal tubulation/sorting driven by LRRK2. bioRxiv : the preprint server for biology (2024)
Mallory Ryan, Justin A McDonough, Michael Emmerson Ward, Mark R Cookson, William C Skarnes, Florian T Merkle
Large structural variants in KOLF2.1J are unlikely to compromise neurological disease modelling. bioRxiv : the preprint server for biology (2024)
Michiyo Iba, Changyoun Kim, Somin Kwon, Marcell P Szabo, Liam Horan-Portelance, Cody J Peer, William Douglas Figg, Xylena Reed, Jinhui Ding, Seung-Jae Lee, Robert A Rissman, Mark R Cookson, Cassia Overk, Wolf Wrasidlo, Eliezer Masliah
Inhibition of p38α MAPK restores neuronal p38γ MAPK and ameliorates synaptic degeneration in a mouse model of DLB/PD. Science translational medicine 15 (695) (2023)
Megan F Duffy, Jinhui Ding, Rebekah G Langston, Syed I Shah, Mike A Nalls, Sonja W Scholz, D Thad Whitaker, Pavan K Auluck, Stefano Marenco, Raphael J Gibbs, Mark R Cookson
Divergent patterns of healthy aging across human brain regions at single-cell resolution reveal links to neurodegenerative disease. bioRxiv : the preprint server for biology (2023)
Iqra Nazish, Adamantios Mamais, Anna Mallach, Conceicao Bettencourt, Alice Kaganovich, Thomas Treharne Warner, John Hardy, Patrick A Lewis, Jennifer Pocock, Mark R Cookson, Rina Bandopadhyay
Differential LRRK2 signalling and gene expression in WT-LRRK2 and G2019S-LRRK2 mouse microglia treated with zymosan and MLi2. bioRxiv : the preprint server for biology (2023)
Fumitaka Kawakami, Motoki Imai, Yuki Isaka, Mark R Cookson, Hiroko Maruyama, Makoto Kubo, Matthew J Farrer, Makoto Kanzaki, Rei Kawashima, Tatsunori Maekawa, Shun Tamaki, Yoshifumi Kurosaki, Fumiaki Kojima, Kenichi Ohba, Takafumi Ichikawa
LRRK2 negatively regulates glucose tolerance via regulation of membrane translocation of GLUT4 in adipocytes. FEBS open bio (2023)
Michiyo Iba, Changyoun Kim, Somin Kwon, Marcell P Szabo, Liam Horan-Portelance, Cody J Peer, William Douglas Figg, Xylena Reed, Jinhui Ding, Seung-Jae Lee, Robert A Rissman, Mark R Cookson, Cassia Overk, Wolf Wrasidlo, Eliezer Masliah
Inhibition of p38α MAPK restores neuronal p38γ MAPK and ameliorates synaptic degeneration in a mouse model of DLB/PD. Science translational medicine 15 (695) (2023)
Riley D Metcalfe, Juliana A Martinez Fiesco, Luis Bonet-Ponce, Jillian H Kluss, Mark R Cookson, Ping Zhang
Structure and regulation of full-length human leucine-rich repeat kinase 1. Nature communications 14 (1) (2023)
Maria Kedariti, Emanuele Frattini, Pascale Baden, Susanna Cogo, Laura Civiero, Elena Ziviani, Gianluca Zilio, Federico Bertoli, Massimo Aureli, Alice Kaganovich, Mark R Cookson, Leonidas Stefanis, Matthew Surface, Michela Deleidi, Alessio di Fonzo, Roy N Alcalay, Hardy Rideout, Greggio Elisa, Nicoletta Plotegher
LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson's disease. NPJ Parkinson's disease 8 (1) (2022)
Rebekah G Langston, Alexandra Beilina, Xylena Reed, Alice Kaganovich, Andrew B Singleton, Cornelis Blauwendraat, Raphael J Gibbs, Mark R Cookson
Association of a common genetic variant with Parkinson's disease is mediated by microglia. Science translational medicine 14 (655) (2022)
Melissa Conti Mazza, Sarah C Shuck, Jiusheng Lin, Michael A Moxley, John Termini, Mark R Cookson, Mark A Wilson
DJ-1 is not a deglycase and makes a modest contribution to cellular defense against methylglyoxal damage in neurons. Journal of neurochemistry 162 (3) (2022)
Luis Bonet-Ponce, Mark R Cookson
The endoplasmic reticulum contributes to lysosomal tubulation/sorting driven by LRRK2. Molecular biology of the cell 33 (13) (2022)
Sara Saez-Atienzar, Sara Bandres-Ciga, Rebekah G Langston, Jonggeol J Kim, Shing Wan Choi, Regina Hertfelder Reynolds, null null, null null, Yevgeniya Abramzon, Ramita Dewan, Sarah Ahmed, John E Landers, Ruth Chia, Mina Ryten, Mark R Cookson, Michael A Nalls, Adriano Chio, Bryan J Traynor
Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types. Science advances 7 (3) (2021)
Stephanie S Sloley, Bevan S Main, Charisse N Winston, Alex C Harvey, Alice Kaganovich, Holly T Korthas, Adam P Caccavano, David N Zapple, Jian-Young Wu, John G Partridge, Mark R Cookson, Stefano Vicini, Mark P Burns
High-frequency head impact causes chronic synaptic adaptation and long-term cognitive impairment in mice. Nature communications 12 (1) (2021)
Dhananjay Yellajoshyula, Samuel S Pappas, Abigail E Rogers, Biswa Choudhury, Xylena Reed, Jinhui Ding, Mark R Cookson, Vikram G Shakkottai, Roman J Giger, William T Dauer
THAP1 modulates oligodendrocyte maturation by regulating ECM degradation in lysosomes. Proceedings of the National Academy of Sciences of the United States of America 118 (31) (2021)
Jillian H Kluss, Melissa Conti Mazza, Yan Li, Claudia Manzoni, Patrick A Lewis, Mark R Cookson, Adamantios Mamais
Preclinical modeling of chronic inhibition of the Parkinson's disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo. Molecular neurodegeneration 16 (1) (2021)
Julie Lake, Xylena Reed, Rebekah G Langston, Mike A Nalls, Ziv Gan Or, Mark R Cookson, Andrew B Singleton, Cornelis Blauwendraat, Hampton L Leonard, null null
Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk. Movement disorders : official journal of the Movement Disorder Society (2021)
Luis Bonet-Ponce, Mark R Cookson
LRRK2 recruitment, activity, and function in organelles. The FEBS journal (2021)
Changyoun Kim, Alexandria Beilina, Nathan Smith, Yan Li, Minhyung Kim, Ravindran Kumaran, Alice Kaganovich, Adamantios Mamais, Anthony Adame, Michiyo Iba, Somin Kwon, Won-Jae Lee, Soo-Jean Shin, Robert A Rissman, Sungyong You, Seung-Jae Lee, Andrew B Singleton, Mark R Cookson, Eliezer Masliah
LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies. Science translational medicine 12 (565) (2021)
Marc Emmenegger, Elena De Cecco, Marian Hruska-Plochan, Timo Eninger, Matthias M Schneider, Melanie Barth, Elena Tantardini, Pierre de Rossi, Mehtap Bacioglu, Rebekah G Langston, Alice Kaganovich, Nora Bengoa-Vergniory, Andrès Gonzalez-Guerra, Merve Avar, Daniel Heinzer, Regina Reimann, Lisa M Häsler, Therese W Herling, Naunehal S Matharu, Natalie Landeck, Kelvin C Luk, Ronald Melki, Philipp J Kahle, Simone Hornemann, Tuomas P J Knowles, Mark R Cookson, Magdalini Polymenidou, Mathias Jucker, Adriano Aguzzi
LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies. EMBO molecular medicine 13 (9) (2021)
Lucia Iannotta, Alice Biosa, Jillian H Kluss, Giulia Tombesi, Alice Kaganovich, Susanna Cogo, Nicoletta Plotegher, Laura Civiero, Evy Lobbestael, Veerle Baekelandt, Mark R Cookson, Elisa Greggio
Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues. Cells 9 (11) (2020)
Estela Area-Gomez, Delfina Larrea, Marta Pera, Rishi R Agrawal, David N Guilfoyle, Leila Pirhaji, Kathleen Shannon, Hirra A Arain, Archana Ashok, Qiuying Chen, Allissa A Dillman, Helen Y Figueroa, Mark R Cookson, Steven S Gross, Ernest Fraenkel, Karen E Duff, Tal Nuriel
APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice. Scientific reports 10 (1) (2020)
Luis Bonet-Ponce, Alexandra Beilina, Chad D Williamson, Eric Lindberg, Jillian H Kluss, Sara Saez-Atienzar, Natalie Landeck, Ravindran Kumaran, Adamantios Mamais, Christopher K E Bleck, Yan Li, Mark R Cookson
LRRK2 mediates tubulation and vesicle sorting from lysosomes. Science advances 6 (46) (2020)
Scott C Vermilyea, Alexander Babinski, Nina Tran, Samantha To, Scott Guthrie, Jillian H Kluss, Jenna Kropp Schmidt, Gregory J Wiepz, Michael G Meyer, Megan E Murphy, Mark R Cookson, Marina E Emborg, Thaddeus G Golos
In Vitro CRISPR/Cas9-Directed Gene Editing to Model LRRK2 G2019S Parkinson's Disease in Common Marmosets. Scientific reports 10 (1) (2020)
Jillian H Kluss, Adamantios Mamais, Mark R Cookson
LRRK2 links genetic and sporadic Parkinson's disease. Biochemical Society transactions 47 (2) (2019)
Mark R Cookson
Proteomics: techniques and applications in neuroscience. Journal of neurochemistry 151 (4) (2019)
Alice S Chen-Plotkin, Roger Albin, Roy Alcalay, Debra Babcock, Vikram Bajaj, Dubois Bowman, Alex Buko, Jesse Cedarbaum, Daniel Chelsky, Mark R Cookson, Ted M Dawson, Richard B Dewey, Tatiana M Foroud, Mark Frasier, Dwight German, Katrina Gwinn, Xuemei Huang, Catherine Kopil, Thomas Kremer, Shirley Lasch, Kenneth Marek, Jarrod A Marto, Kalpana M Merchant, Brit Mollenhauer, Anna Naito, Judith A Potashkin, Alyssa Reimer, Liana S Rosenthal, Rachel Saunders-Pullman, Clemens R Scherzer, Todd Sherer, Andrew Singleton, Margaret Sutherland, Ines Thiele, Marcel van der Brug, Kendall Van Keuren-Jensen, David E Vaillancourt, David Walt, Andrew West, Jing Zhang
Finding useful biomarkers for Parkinson's disease. Science translational medicine 10 (454) (2019)
Yan Li, Mark R Cookson
Proteomics; applications in familial Parkinson's disease. Journal of neurochemistry 151 (4) (2019)
Rebekah G Langston, Iakov N Rudenko, Ravindran Kumaran, David N Hauser, Alice Kaganovich, Luis Bonet Ponce, Adamantios Mamais, Kelechi Ndukwe, Allissa A Dillman, Amr M Al-Saif, Aleksandra Beilina, Mark R Cookson
Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2. Neurochemical research 44 (6) (2018)
Li Gan, Mark R Cookson, Leonard Petrucelli, Albert R La Spada
Converging pathways in neurodegeneration, from genetics to mechanisms. Nature neuroscience 21 (10) (2018)
Marc P M Soutar, Liam Kempthorne, Shuichi Miyakawa, Emily Annuario, Daniela Melandri, Jasmine Harley, Gregory A O'Sullivan, Selina Wray, David C Hancock, Mark R Cookson, Julian Downward, Mark Carlton, Hélène Plun-Favreau
AKT signalling selectively regulates PINK1 mitophagy in SHSY5Y cells and human iPSC-derived neurons. Scientific reports 8 (1) (2018)
Jillian H Kluss, Melissa M Conti, Alice Kaganovich, Aleksandra Beilina, Heather L Melrose, Mark R Cookson, Adamantios Mamais
Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity. NPJ Parkinson's disease 4 (2018)
Allissa A Dillman, Elisa Majounie, Jinhui Ding, J Raphael Gibbs, Dena Hernandez, Sampath Arepalli, Bryan J Traynor, Andrew B Singleton, Dagmar Galter, Mark R Cookson
Transcriptomic profiling of the human brain reveals that altered synaptic gene expression is associated with chronological aging. Scientific reports 7 (1) (2017)