Epigenetic Regulation of Inflammatory Mechanisms and a Psychological Symptom Cluster in Patients Receiving Chemotherapy.
Carolyn S HarrisChristine A MiaskowskiYvette P ConleyMarilyn J HammerLaura B DunnAnand A DhruvaJon D LevineAdam B OlshenKord M KoberPublished in: Nursing research (2023)
This study is the first to suggest associations between a psychological symptom cluster and differential DNA methylation of a gene involved in tissue inflammation and cell-mediated immunity. Our findings suggest that increased CD40 expression through hypomethylation of promoter eCpG loci is involved in the occurrence of a psychological symptom cluster in patients receiving chemotherapy. These findings suggest a direction for mechanistic studies.
Keyphrases
- dna methylation
- genome wide
- oxidative stress
- gene expression
- locally advanced
- patient reported
- sleep quality
- poor prognosis
- copy number
- risk assessment
- single cell
- transcription factor
- cell therapy
- stem cells
- squamous cell carcinoma
- physical activity
- binding protein
- depressive symptoms
- rectal cancer
- mesenchymal stem cells
- genome wide association
- genome wide analysis