ATP-dependent citrate lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling of the Heart.
Shijie LiuSeth T GammonLin TanYaqi GaoKyoungmin KimIan K WilliamsonJanet PhamAngela DavidianRadhika KhannaBenjamin D GouldRebecca SalazarHeidi VitracAn DinhEvan C LienFrancisca N de L VitorinoJoanna M GongoraSara A MartinezCzer S C LawrenceEvan P KransdorfDavid LefferBlake HansonBenjamin A GarciaMatthew G Vander HeidenPhilip L LorenziHeinrich TaegtmeyerDavid Piwnica-WormsJames F MartinAnja KarlstaedtPublished in: bioRxiv : the preprint server for biology (2024)
This study mechanistically delineates how cardiac metabolism compensates for suppressed citrate metabolism in response to ACL loss and uncovers metabolic vulnerabilities in the heart.