Wait and see: a case of EBV + cutaneous extranodal NK/T-type lymphoma with indolent behaviour.
Italo Francesco AromoloCarlo PesciaDomenico SimeoliSilvia Alberti ViolettiValeria FerlaFrancesca Gaia RossiGiorgio Alberto CrociPublished in: Virchows Archiv : an international journal of pathology (2023)
Extranodal NK/T-cell lymphoma (ENKTL) is a rare lymphoma subtype associated with Epstein-Barr virus (EBV) infection, portending a poor prognosis despite systemic chemotherapy. We present the unusual case of an 85-year-old man receiving ibrutinib for mantle cell lymphoma, who developed a erythematous, subcutaneous nodule on the forehead, featuring a proliferation of pleomorphic CD8 + /CD56 - /EBV + cells. Given the negative staging and comorbidities, a watchful waiting strategy was performed, experiencing a benign course with self-resolution and complete remission over a 4-year follow-up. The literature on primary cutaneous ENKTL has been discussed, with particular attention to clinical and histological prognostic factors.
Keyphrases
- epstein barr virus
- diffuse large b cell lymphoma
- poor prognosis
- prognostic factors
- long non coding rna
- induced apoptosis
- systematic review
- signaling pathway
- cell cycle arrest
- nk cells
- lymph node
- single molecule
- pet ct
- squamous cell carcinoma
- disease activity
- oxidative stress
- radiation therapy
- rheumatoid arthritis
- systemic lupus erythematosus