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Sacituzumab Govitecan Versus Docetaxel for Previously Treated Advanced or Metastatic Non-Small Cell Lung Cancer: The Randomized, Open-Label Phase III EVOKE-01 Study.

Luis G Paz-AresOscar Juan VidalGiannis S MountziosEnriqueta Felip FontNiels ReinmuthFilippo de MarinisNicolas GirardVipul M PatelTakayuki TakahamaScott P OwenDouglas M ReznickFiras B BadinIrfan CicinSabeen MekanRiddhi PatelEric ZhangDivyadeep KarumanchiMarina-Chiara Garassino
Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)
Although statistical significance was not met, OS numerically improved with SG versus docetaxel, which was consistent across histologies. Clinically meaningful improvement in OS was noted in mNSCLC nonresponsive to last anti-PD-(L)1-containing regimen. SG was better tolerated than docetaxel and consistent with its known safety profile, with no new safety signals.
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