Toll-Like Receptor 3 as a Recurrence Risk Factor and a Potential Molecular Therapeutic Target in Colorectal Cancer.

Tatsuya Yoshida Takuya MiuraTomoh MatsumiyaHidemi YoshidaHajime MorohashiYoshiyuki SakamotoAkira KuroseTadaatsu ImaizumiKenichi Hakamada

Published in: Clinical and experimental gastroenterology (2020)

Non-expression of TLR3 in CRC cells was associated with lymph node metastasis and was an independent risk factor for recurrence. These results suggest that TLR3 may not only be used as a prognostic factor and a risk factor for recurrence, but further studies on the involvement of TLR3 with tumor growth may provide new therapeutic strategies.

Keyphrases

toll like receptor
lymph node metastasis
inflammatory response
prognostic factors
nuclear factor
immune response
free survival
induced apoptosis
squamous cell carcinoma
risk factors
poor prognosis
papillary thyroid
cell cycle arrest
endoplasmic reticulum stress
cell proliferation
human health
case control