Loss of 12-Lipoxygenase Improves the Post-Transfusion Function of Stored Platelets.
Hannah J LarsenDaire ByrneTahsin ÖzpolatAastha ChauhanS Lawrence BaileyNicole M RhoadsFranklin ReedMassiel C StollaReheman AdiliMichael A HolinstatXiaoyun FuMoritz StollaPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
Deleting 12-LOX improves the post-transfusion function of stored murine platelets by increasing thromboxane generation through COX-1-dependent arachidonic acid metabolism. Future studies should determine the feasibility and safety of 12-LOX-inhibited platelets transfused to humans.